OXIDATION-PRODUCTS OF PHENOLIC THIOCOLCHICINES - RING A QUINONES AND DIENONES

Authors
GUAN J BROSSI A ZHU XK WANG HK LEE KH
Citation
J. Guan et al., OXIDATION-PRODUCTS OF PHENOLIC THIOCOLCHICINES - RING A QUINONES AND DIENONES, Synthetic communications, 28(9), 1998, pp. 1585-1591
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
28
Issue
9
Year of publication
1998
Pages
1585 - 1591
Database
ISI
SICI code
0039-7911(1998)28:9<1585:OOPT-R>2.0.ZU;2-Q
Abstract
An improved, highly selective demethylation of thiocolchicine (1) to t he diphenol 5 is described. Oxidation of 2 to para-quinone 6 and of 4 and 5 to ortho-quinones 8 and 10 is first reported. Also, 2-demethylth iocolchicine (3) was oxidized to the quinone methide 7.