EFFICIENT PREPARATION OF GAMMA-HYDROXYNITRILES VIA NITRILE ENOLATE-EPOXIDE REACTIONS - SCOPE AND DIASTEREOSELECTIVITY

Authors
TAYLOR SK DEYOUNG D SIMONS LJ VYVYAN JR WEMPLE MA WOOD NK
Citation
Sk. Taylor et al., EFFICIENT PREPARATION OF GAMMA-HYDROXYNITRILES VIA NITRILE ENOLATE-EPOXIDE REACTIONS - SCOPE AND DIASTEREOSELECTIVITY, Synthetic communications, 28(9), 1998, pp. 1691-1701
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
28
Issue
9
Year of publication
1998
Pages
1691 - 1701
Database
ISI
SICI code
0039-7911(1998)28:9<1691:EPOGVN>2.0.ZU;2-G
Abstract
The nucleophilic opening of epoxides by nitrile enolates using an effi cient, convenient protocol is described The diastereoselectivity of th is reaction was explored and found to give syn:anti ratios ranging fro m 1.1:1.0 to 4.8:1.0.