AN IMPROVED LARGE-SCALE PREPARATION OF BENZIMIDAZOLE-2-SULFONIC ACIDSAND 2-CHLOROBENZIMIDAZOLES

Authors
HINKLEY JM PORCARI AR WALKER JA SWAYZE EE TOWNSEND LB
Citation
Jm. Hinkley et al., AN IMPROVED LARGE-SCALE PREPARATION OF BENZIMIDAZOLE-2-SULFONIC ACIDSAND 2-CHLOROBENZIMIDAZOLES, Synthetic communications, 28(9), 1998, pp. 1703-1712
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
28
Issue
9
Year of publication
1998
Pages
1703 - 1712
Database
ISI
SICI code
0039-7911(1998)28:9<1703:AILPOB>2.0.ZU;2-A
Abstract
An improved method for the preparation of benzimidazole-2-sulfonic aci ds from 2-mercaptobenzimidazoles has been developed which utilizes aqu eous sodium percarbonate. 2-Chlorobenzimidazoles were obtained in high yield from the corresponding sulfonic acids upon reaction with PCl5 i n POCl3 on a gram-mole scale.