THE EFFECTS OF COMMONLY USED ADULTERANTS ON THE DETECTION OF SPIKED LSD BY AN ENZYME-IMMUNOASSAY

The effects of 15 chemicals and household agents on an enzyme immunoas say (EIA) for LSD were investigated. The presence of many of these was detected by pH and specific gravity measurements and by sample inspec tion. A number of agents caused false positives in the assay at 10% ad ulteration, but only two produced false positive results at 1%. Adulte rated samples spiked with LSD produced no false negatives, demonstrati ng that none of the adulterants tested were able to conceal the presen ce of LSD by interfering with the EIA. The assay is shown to be a robu st method for the screening of urine for LSD when used in conjunction with sample inspection and a sound confirmatory method.