SYNTHESIS OF PYRAZINO[2,3-E][1,4]DIAZEPIN-5-ONE AND PYRAZINO[2,3-E]PYRROLO[1,2-A][1,4]DIAZEPIN-5-ONE DERIVATIVES VIA THE INTRAMOLECULAR AZA-WITTING REACTION

Authors
OKAWA T EGUCHI S
Citation
T. Okawa et S. Eguchi, SYNTHESIS OF PYRAZINO[2,3-E][1,4]DIAZEPIN-5-ONE AND PYRAZINO[2,3-E]PYRROLO[1,2-A][1,4]DIAZEPIN-5-ONE DERIVATIVES VIA THE INTRAMOLECULAR AZA-WITTING REACTION, Tetrahedron, 54(22), 1998, pp. 5853-5868
Citations number
34
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
22
Year of publication
1998
Pages
5853 - 5868
Database
ISI
SICI code
0040-4020(1998)54:22<5853:SOPAP>2.0.ZU;2-W
Abstract
2-Alkoxy pyrazino[2,3-e][1,4]diazepin-5-one and 11-alkoxy pyrazino[2,3 -e]pyrrolo[1,2-a][1,4ldiazepin-5-one derivatives were synthesized via the corresponding iminophosphoranes derived from 3-aminopyrazine-2-car boxylic acid and a-amino acid derivatives, by the intramolecular aza-W ittig methodology. (11S, y-pyrazino[2,3-e]pyrrolo[1,2-a][1,4]diazepin- 5-one derivatives, i.e.. 6,9-diaza-analogs of porothramycin B etc., we re obtained. (C) 1998 Elsevier Science Ltd. All rights reserved.