G. Haufe et al., SYNTHESIS OF GAMMA-FLUORO-ALPHA-METHYL-ALPHA-AMINO ACIDS - A NEW ALKYLATION PROCEDURE FOR ESTER IMINES, Tetrahedron, 54(22), 1998, pp. 5929-5938
Deprotonation of alanine ester imines with KO'Bu in DMSO or DMF and al
kylation of the formed enolates with several 2-fluoroalkyl halogenides
2 and subsequent hydrolysis of the imino and the ester groups are pre
sented as an efficient three-step sequence fbr the synthesis of racemi
c title compounds 5. (C) 1998 Elsevier Science Ltd. All rights reserve
d.