CHIRALITY OF REDUCED HALOPERIDOL IN HUMANS

Authors
EYLES DW MCGRATH JJ STEDMAN TJ POND SM
Citation
Dw. Eyles et al., CHIRALITY OF REDUCED HALOPERIDOL IN HUMANS, European neuropsychopharmacology, 8(2), 1998, pp. 127-129
Citations number
9
Categorie Soggetti
Neurosciences,"Clinical Neurology","Pharmacology & Pharmacy
Journal title
European neuropsychopharmacology → ACNP
ISSN journal
0924977X
Volume
8
Issue
2
Year of publication
1998
Pages
127 - 129
Database
ISI
SICI code
0924-977X(1998)8:2<127:CORHIH>2.0.ZU;2-H
Abstract
In vitro, cytosolic human ketone reductases catalyse the stereospecifi c (i.e. >99%) formation of S(-) reduced haloperidol (RHP) from haloper idol (HP). Whether this situation is reflected in patients taking the drug is unknown. In this study in nine patients taking HP, only 73.2+/ -18.2% of the RHP excreted in urine was the S(-) enantiomer. Thus, enz ymes other than cytosolic ketone reductases must be responsible for th e formation of the minor enantiomer. (C) 1998 Elsevier Science B.V./EC NP.