Accident and Emergency Departments offer a unique opportunity for iden
tifying and monitoring new drugs of misuse. This series of sis case re
ports describes the potentially serious medical complications associat
ed with the use of gamma-hydroxybutyrate (GHB) a new drug of misuse on
the UK scene. Profound unconsciousness occurred in all cases and desp
ite full (and often rapid) recovery all patients required medical inte
rvention. Adverse effects occurred both when GHB was used alone or in
combination with other illicit drugs and alcohol.