In the care of patients with voice disorders, physicians, speech patho
logists, and other health care professionals routinely make diagnoses,
recommend treatment, and evaluate outcomes. Although objective and su
bjective measures exist, unfortunately, then is no widely accepted, va
lid method for classifying voice disorders and assessing outcome after
voice treatment. In the present research, the relationship between tw
o previously created multivariate objective voice function indices, th
e weighted odds ratio index and the multivariate logistic regression i
ndex, and subjective assessment of voice function was evaluated. Twent
y-three adult patients presenting to a speech science laboratory for e
valuation of voice disorders were studied in this prospective observat
ional study together with 12 normal volunteers as controls. Vocal func
tion was measured on 14 different parameters with a protocol that incl
uded a multichannel input for simultaneous assessment of acoustic and
physiological parameters. Each patient was recorded reading the standa
rd passage ''The North Wind and the Sun,'' and recordings were then ev
aluated by the GRBAS scale. Overall, there was a statistically signifi
cant relationship between the weighted odds ratio index and multivaria
te logistic regression index and mean GRBAS scores. This research demo
nstrates that the voice function values calculated from two different
multivariate objective voice function indices are significantly associ
ated with subjective voice assessments. These multivariate objective v
oice indices may be appropriate for use in clinical trials and outcome
s research on treatment effectiveness for voice disorders.