Acute necrotizing ulcerative gingivitis-periodontitis (ANUG/NUP) is a
relatively uncommon periodontal disease characterized by gingival necr
osis and ulceration, pain, and bleeding, The purpose of this paper is
to provide a review of current knowledge on ANUG/NUP. Current literatu
re on the epidemiology, pathogenesis, immunology, predisposing factors
, and treatment of ANUG/NUP is reviewed.