Volatile substance abuse is the deliberate inhalation of volatile subs
tances to achieve intoxication. We discuss the history and pathophysio
logical effects of commonly abused volatile substances. We explore thr
ee deaths and one serious accident in active duty military settings. T
he causes for abuse in the military environment are numerous and inclu
de remote duty, peer influence, low cost, rapid onset, limitation of e
thanol use, difficult detection/screening for use, and lack of knowled
ge among users and authorities. The lethality of these substances and
their casual use can constitute a threat to military readiness. Our ex
perience suggests an increase in the use of these substances in the mi
litary paralleling their increasing use in the general population. Edu
cation and awareness training could limit fatalities and decrease the
threat in military and civilian populations.