SOTALOL ASSOCIATED TORSADES-DE-POINTES TACHYCARDIA IN A 15-MONTH-OLD CHILD - SUCCESSFUL THERAPY WITH MAGNESIUM ASPARTATE

Citation
M. Sasse et al., SOTALOL ASSOCIATED TORSADES-DE-POINTES TACHYCARDIA IN A 15-MONTH-OLD CHILD - SUCCESSFUL THERAPY WITH MAGNESIUM ASPARTATE, PACE, 21(5), 1998, pp. 1164-1166
Citations number
13
Categorie Soggetti
Cardiac & Cardiovascular System","Engineering, Biomedical
Journal title
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
ISSN journal
01478389 → ACNP
Volume
21
Issue
5
Year of publication
1998
Pages
1164 - 1166
Database
ISI
SICI code
0147-8389(1998)21:5<1164:SATTIA>2.0.ZU;2-9
Abstract
Torsades de pointes (Tdp) is a form of ventricular tachycardia, and it s occurrence in childhood is very rare. In adult patients treated with sotalol, Tdp has been reported to the occur with an incidence of 2%-4 %. In children who are treated with sotalol, occurrence of Tdp has bee n reported in only a single case. A 15-month-old girl with Wolff-Parki nson-White syndrome developed recurrent syncopal attacks. She had been treated with sotalol 1.5 mg/kg daily since shortly after birth becaus e of recurrent episodes of paroxysmal supraventricular tachycardia. EC G monitoring exhibited frequent Tdp tachycardia. Serum electrolyte lev els were normal. Echocardiographic analysis excluded a structural hear t defect and did not show any signs of myocardial infection. Sotalol t reatment was stopped and an infusion with lidocaine was started. Despi te this therapy the Tdp continued. Magnesium aspartate rr as then admi nistered, which immediately stopped the Tdp. As no other reason was ev ident, Tdp in this child has to be judged as a proarrhythmia related t o sotalol therapy.