SYNTHESIS OF SOME INDANE DERIVATIVES OF CENTRAL MUSCLE-RELAXANT AND ANTICONVULSANT PROFILES

Authors
ABDALLAH NA ELSHABRAWY O ELERAKY W
Citation
Na. Abdallah et al., SYNTHESIS OF SOME INDANE DERIVATIVES OF CENTRAL MUSCLE-RELAXANT AND ANTICONVULSANT PROFILES, Il Farmaco, 52(12), 1997, pp. 733-739
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
52
Issue
12
Year of publication
1997
Pages
733 - 739
Database
ISI
SICI code
0014-827X(1997)52:12<733:SOSIDO>2.0.ZU;2-Y
Abstract
A series of 2,2-bis(hydroxymethyl)indane derivatives 1a-f, 2a-e and 3a -f were synthesized to investigate their central muscle relaxant and a nticonvulsant activities. The synthesized compounds 1a-f, 2a-e and 3a- f were found to be devoid of central muscle relaxant activity using me probamate (100 mg/kg) as a reference standard. However, they showed re markable anticonvulsant properties in a dose of 80 mg/kg (sc) compared with diphenylhydantoin sodium (80 mg/kg) as a reference standard.