(2-PYRIDINYL)-2-[2(3H)-BENZAZOLONE-3-YL]ACETAMIDES - SYNTHESIS, ANTINOCICEPTIVE AND ANTIINFLAMMATORY ACTIVITY

Authors
DOGRUER DS UNLU S YESILADA E SAHIN MF
Citation
Ds. Dogruer et al., (2-PYRIDINYL)-2-[2(3H)-BENZAZOLONE-3-YL]ACETAMIDES - SYNTHESIS, ANTINOCICEPTIVE AND ANTIINFLAMMATORY ACTIVITY, Il Farmaco, 52(12), 1997, pp. 745-750
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
52
Issue
12
Year of publication
1997
Pages
745 - 750
Database
ISI
SICI code
0014-827X(1997)52:12<745:(-SA>2.0.ZU;2-K
Abstract
Eighteen N-(2-Pyridyl)-2-[2(3H)-benzazolone-3-yl]acetamide derivatives have been synthesized. The chemical structure of the compounds have b een elucidated by elemental analysis. IR and H-1 NMR spectral data and their antinociceptive and anti-inflammatory activities were tested in mice. Compound VII o has shown the highest antinociceptive activity, and Vn g,j, k, r exhibited relatively high antinociceptive activity. I n addition, compounds VII d, f,j, p showed statistically significant a nti-inflammatory activity.