Background and objectives. Concern about the inadequate take-up of gui
delines in general practice has concentrated on problems arising from
the process of their development and implementation. However, these pe
rspectives fail to take account of the needs, attitudes and problems o
f GPs themselves. In this study we aimed to identify barriers to the u
se of guidelines and opportunities for tackling them, from the point o
f view of the GP, so that future guideline development and policy coul
d be more sensitive to the needs of GPs in the environment in which th
ey work. Method. Twenty in-depth semi-structured interviews were audio
taped with GPs from within the Avon Health Authority area, representin
g GPs with different backgrounds and working environments. The transcr
ibed data collected were analysed using a grounded theory approach. Re
sults. Utilization of guideline information is complex. GPs' appraisal
s of the value of guidelines interact with prior knowledge and beliefs
, practicalities of existing information storage and retrieval systems
, and individual working practices. Conditions where guidelines are mo
st likely to be referred to may be those either very rarely or very co
mmonly presenting in general practice. Key issues for the uptake of gu
idelines in the consultation are: general preference for certain forma
ts of presentation; reputability and ownership; use of guidelines in s
hared decision-making; scope for computer-based systems; and GPs attit
udes to time pressures on information-seeking in relation to tolerance
of uncertainty. Conclusion. Local initiatives might usefully explore
the possibilities of supporting development of guideline-retrieval sys
tems customized for individual GPs or practices. Novel means of stimul
ating 'ownership' and demonstrating reputability should be sought. The
analysis provides a framework for understanding the complexities of t
he processes of GPs' use of guidelines in practice which can be useful
in explaining the results of trials of guideline effectiveness. Guide
line implementation occurs in the context of conflicting pressures for
clinical autonomy and professional standardization and quality improv
ement.