Reduced pain perception has been observed in many studies of spontaneo
usly hypertensive rats and human hypertensive patients. To determine w
hether a reduced sensitivity to pain could be observed in a group of c
learly normotensive individuals who may be at risk for hypertension, a
mild to moderate pain stimulus was administered to 177 14-year-old bo
ys. Boys with a normatively elevated resting systolic blood pressure t
olerated mechanical finger pressure significantly longer than boys wit
h lower blood pressure. As well, boys with both normatively elevated r
esting systolic blood pressure and a parental history of hypertension
reported significantly less pain during finger pressure than lower ris
k participants. These findings could not be explained by personality f
actors and suggest that hypertension-related hypoalgesia is associated
with processes involved in the development of the disorder.