Tuberculosis is transmitted from patients with lung disease to sensiti
ve individuals by inhalation of infectious particles expelled during c
ough. Therefore, the search for infected subjects among relatives of p
atients with infectious tuberculosis is the best method of preventing
later development of the disease in populations where the prevalence o
f tuberculosis is low. Contact tracing relies on the tuberculin skin t
est, followed by chest X-ray if indicated and bacteriological examinat
ion of sputum. In recently infected subjects, particularly the young,
preventive chemotherapy has been shown to decrease the risk of later d
isease.