EFFECT OF HYPERGLYCEMIA ON PYRUVATE-DEHYDROGENASE ACTIVITY AND ENERGYMETABOLITES DURING ISCHEMIA AND REPERFUSION IN GERBIL BRAIN

Authors
KATAYAMA Y FUKUCHI T MCKEE A TERASHI A
Citation
Y. Katayama et al., EFFECT OF HYPERGLYCEMIA ON PYRUVATE-DEHYDROGENASE ACTIVITY AND ENERGYMETABOLITES DURING ISCHEMIA AND REPERFUSION IN GERBIL BRAIN, Brain research, 788(1-2), 1998, pp. 302-304
Citations number
20
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
Volume
788
Issue
1-2
Year of publication
1998
Pages
302 - 304
Database
ISI
SICI code
Abstract
The effects of hyperglycemia on brain pyruvate dehydrogenase (PDH) and metabolites (ATP, PCr, and lactate) were investigated at 20 min ische mia, 0, 20, and 60 min, and 4 h reperfusion. During reperfusion, PDH a ctivities were suppressed corresponding to the poor recovery of ATP an d PCr concentrations and the increase in lactate concentration in the hyperglycemic group, suggesting that preischemic hyperglycemia may imp air metabolism by suppressing PDH activity. (C) 1998 Elsevier Science B.V.