COMBINED ORCHIECTOMY AND EXTERNAL RADIOTHERAPY VERSUS RADIOTHERAPY ALONE FOR NONMETASTATIC PROSTATE-CANCER WITH OR WITHOUT PELVIC LYMPH-NODE INVOLVEMENT - A PROSPECTIVE RANDOMIZED STUDY
T. Granfors et al., COMBINED ORCHIECTOMY AND EXTERNAL RADIOTHERAPY VERSUS RADIOTHERAPY ALONE FOR NONMETASTATIC PROSTATE-CANCER WITH OR WITHOUT PELVIC LYMPH-NODE INVOLVEMENT - A PROSPECTIVE RANDOMIZED STUDY, The Journal of urology, 159(6), 1998, pp. 2030-2034
Purpose: We compare the combination of orchiectomy and radiotherapy to
radiotherapy alone as treatment for pelvic confined prostate cancer,
that is T1-4, pN0-3, M0 (TNM classification). Materials and Methods: I
n this prospective study 91 patients with clinically localized prostat
e cancer were, after surgical lymph node staging, randomized to receiv
e definitive external beam radiotherapy (46) or combined orchiectomy a
nd radiotherapy (45). Patients treated with radiotherapy alone had and
rogen ablation at clinical disease progression. The effects on progres
sion-free, disease specific and overall survival rates were calculated
. Results: After a median followup of 9.3 years (range 6.0 to 11.4) cl
inical progression was seen in 61% of the radiotherapy only patients (
group 1) and in 31% of the combined treatment patients (group 2) (p =
0.005). The mortality was 61 and 38% (p = 0.02), and cause specific mo
rtality was 44 and 27%, respectively (p = 0.06), in groups 1 and 2. Th
e differences in favor of combined treatment were mainly caused by lym
ph node positive tumors. For node negative tumors there was no signifi
cant difference in survival rates. Conclusions: The progression-free,
disease specific and overall survival rates for patients with prostate
cancer and pelvic lymph node involvement are significantly better aft
er combined androgen ablation and radiotherapy than after radiotherapy
alone. These results strongly suggest that early androgen deprivation
is better than deferred endocrine treatment for these patients.