EXPERIMENTAL-MODEL OF RENOVASCULAR HYPERTENSION

Objective. To establish a model of renovascular hypertension. Methods. A 4/0 resorbable chromic catgut ligature was used to ligate subtotall y the renal arteries of 18 dogs, forming experimental renovascular hyp ertension steadily. Blood pressure, plasma renin activity, the ultrast ructural changes of juxtaglomerular apparatus and renal artery wall we re studied after the constriction. Results. It was reasonable that ren al blood flow measured with an electromagnetic flowmeter was reduced b y 30% after the constriction. The pathological changes of the induced renal artery stenosis were similar to those of fibromuscular dysphasia . Conclusion. The findings provide valuable evidence for the treatment of renovascular hypertension.