NMR ASSIGNMENTS AND CONFORMATIONAL STUDIES OF 2 DIASTEREOMERIC OXIDATION-PRODUCTS OF 2'-DEOXYCYTIDINE

Authors
AMMALAHTI E BARDET M CADET J MOLKO D
Citation
E. Ammalahti et al., NMR ASSIGNMENTS AND CONFORMATIONAL STUDIES OF 2 DIASTEREOMERIC OXIDATION-PRODUCTS OF 2'-DEOXYCYTIDINE, Magnetic resonance in chemistry, 36(5), 1998, pp. 363-370
Citations number
22
Categorie Soggetti
Spectroscopy,Chemistry,"Chemistry Physical
Journal title
Magnetic resonance in chemistry → ACNP
ISSN journal
07491581
Volume
36
Issue
5
Year of publication
1998
Pages
363 - 370
Database
ISI
SICI code
0749-1581(1998)36:5<363:NAACSO>2.0.ZU;2-9
Abstract
Structural assignment and conformational features of two diastereomeri c oxidation products of 2'-deoxycytidine, the 5S and 5R* diastereomer s of -beta-D-erythro-pentofuranosyl)-5-hydroxyhydantoin were achieved by combining NMR studies and restrained molecular dynamics. Interproto n distances were measured from NOESY and ROESY experiments. The absolu te configuration of these two compounds was unambiguously determined a nd their conformation properties in solution were also studied. (C) 19 98 John Wiley & Sons. Ltd.