SYNTHESIS OF METHYL (5Z,8Z,11Z,14Z,17Z)-[18-C-14] AND (5Z,8Z,11Z,14Z,17E)-[18-C-14] EICOSAPENTAENOATE

Authors
EYNARD T POULLAIN D VATELE JM NOEL JP CHARDIGNY JM SEBEDIO JL
Citation
T. Eynard et al., SYNTHESIS OF METHYL (5Z,8Z,11Z,14Z,17Z)-[18-C-14] AND (5Z,8Z,11Z,14Z,17E)-[18-C-14] EICOSAPENTAENOATE, Journal of labelled compounds & radiopharmaceuticals, 41(5), 1998, pp. 411-421
Citations number
26
Categorie Soggetti
Chemistry Analytical","Chemistry Medicinal","Biochemical Research Methods","Pharmacology & Pharmacy
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
41
Issue
5
Year of publication
1998
Pages
411 - 421
Database
ISI
SICI code
0362-4803(1998)41:5<411:SOM(A(>2.0.ZU;2-U
Abstract
In order to have a better insight of the effect of the double bond geo metry of EPA on its anti-aggregating properties, methyl ester of [18-C -14] EPA and of its Delta 17t isomer were synthesized from a common in termediate -diethoxydodeca-3,6,9-trienyl]triphenylphosphonium iodide 1 1 via three sequential Wittig olelination. Labelled methyl ester of EP A 16b and EPA Delta 17t 17b were obtained in near 100% isomeric and ra diochemical purities.