Primary nail invasion by Candida is uncommon and almost exclusively se
en in patients with an impaired immune function. The appearance of Can
dida onychomycosis in an adult who is not under immunosuppressive trea
tment always requires a laboratory evaluation of the immunologic funct
ion including HIV assays. We report 2 cases of distal subungual onycho
mycosis due to Candida sp. in HIV. In one of our patients, the diagnos
is of Candida onychomycosis preceded the diagnosis of advanced HIV inf
ection. In both of our patients treatment with systemic antifungals pr
oduced complete cure of Candida onychomycosis and the 1 year follow-up
did not reveal any relapse of the onychomycosis.