PROTECTIVE EFFECTS OF CRUCIFEROUS SEED MEALS AND HULLS AGAINST COLON-CANCER IN MICE

Protective effects of diets containing cruciferous seed meals or hulls against chemically-induced colon tumors were examined in male CF1 mic e. When commercial crambe meal, autolyzed crambe meal, crambe hulls, h igh glucosinolate rapeseed meal, or canola meal were fed as 12% of the diets of mice injected with 1,2-dimethylhydrazine, 25-80% of the anim als developed colon tumors. Animals fed a soybean meal control diet ha d a 100% tumor rate. Data suggest that cruciferous seed meals may cont ain a number of compounds that can exert protective effects against tu mor formation and growth. (C) 1998 Elsevier Science Ireland Ltd.