Analysts have a variety of methods at their disposal to speed and cut
the cost of sample preparation for gas chromatography (GC) analysis of
pharmaceutical samples: These methods include headspace GC; supercrit
ical fluid, accelerated solvent, and microwave-assisted extraction; an
d large-volume GC injection. All these methods have the potential to c
ope with low analyte concentrations and large amounts of interfering s
ubstances.