Recognition of children at greatest risk for urolithiasis may allow ea
rly detection or prevention of stone formation. We report clinical dat
a from 196 children aged 0.9-15.9 years in whom renal ultrasound exami
nation revealed hyperechogenic spots in renal calyces less than 3 mm i
n diameter. We called this finding ''calyceal microlithiasis'' (CM). T
here was a history of urolithiasis in 70.4% of patients in at least on
e first-or second-degree relative. Presenting symptoms were recurrent
abdominal pain, dysuria, and hematuria, occurring alone or in combinat
ion. Hematuria was the presenting symptom in 41% of patients and was t
he only urinary finding in more than one-third. Hypercalciuria was pre
sent in about one-third and hyperuricuria in one-fifth of the patients
. Of 29 patients who were followed for at least 2 years, 9 developed c
alculi 4-7 mm in diameter. CM possibly represents the first step in ca
lculus formation. The finding of CM might explain a number of symptoms
and signs that are often mild and non-specific, thus reducing invasiv
e diagnostic procedures.