ANTIPROLIFERATIVE EFFECTS ON HUMAN COLON-CANCER CELLS OF COMBINED TREATMENT WITH CATIONIC LIPOSOME-ENTRAPPED HUMAN INTERFERON-BETA OR INTERFERON-GAMMA GENE AND ANTICANCER DRUG

Authors
SHIMIZU M AKIYAMA S ITO K KASAI Y TAKAGI H KITO M OHISHI N YAGI K
Citation
M. Shimizu et al., ANTIPROLIFERATIVE EFFECTS ON HUMAN COLON-CANCER CELLS OF COMBINED TREATMENT WITH CATIONIC LIPOSOME-ENTRAPPED HUMAN INTERFERON-BETA OR INTERFERON-GAMMA GENE AND ANTICANCER DRUG, Journal of clinical biochemistry and nutrition, 23(2), 1997, pp. 77-83
Citations number
28
Journal title
Journal of clinical biochemistry and nutrition → ACNP
ISSN journal
09120009
Volume
23
Issue
2
Year of publication
1997
Pages
77 - 83
Database
ISI
SICI code
0912-0009(1997)23:2<77:AEOHCC>2.0.ZU;2-F
Abstract
Effects on cultured human colon cancer cells of combination of transfe ction with cationic multilamellar liposome-entrapped plasmids containi ng cDNA of human interferon-beta (hIFN-beta) or interferon-gamma (hIFN -gamma) (RN-hIFN-beta or RN-hIFN-gamma) and an anti-cancer drug (5-flu orouracil or cisplatin) were examined. At 16 h after the addition of l iposome-entrapped RN-hIFN-beta or RN-hIFN-gamma, the medium was exchan ged for the fresh medium containing anti-cancer drug, of which effect of growth inhibition was strengthened synergistically, and the efficac y increased corresponding to the dose of the drug.