Background Non-compliance rates with antipsychotic medication can be h
igh. and the personal and societal costs are considerable. A new psych
ological intervention. compliance therapy seeks to improve compliance
and patient outcomes and reduce treatment costs. Method A randomised c
ontrolled study examined the cost-effectiveness of compliance therapy
compared to nonspecific counselling over 18 months for 74 people with
psychosis admitted as inpatients at the Maudsley Hospital. Bivariate a
nd multivariate analyses were conducted to test for differences and to
explore inter-patient cost variations. Results Compliance therapy is
more effective and is no more expensive. Consequently, compliance ther
apy is more cost-effective than non-specific counselling at six, 12 an
d 18 months. Conclusions There are compliance, outcome and cost-effect
iveness arguments in favour of compliance therapy in preference to non
-specific counselling.