PHOSPHORUS-BASED COMBINATORIAL LIBRARIES - USE OF AMINO-ACID DERIVATIVES AS SYNTHONS

Phosphorus has been used as a scaffold to prepare combinatorial librar ies of phosphoramidates in which one of the diversity elements resulte d from derivatives of amino acids. A small library was prepared for an alytical and characterization purposes, followed by a larger library o f approximately 8800 compounds. Libraries were assembled on solid supp orts using the conventional pool-and-divide method, followed by cleava ge from the supports at the end of the synthesis. Mass spectrometry wa s used to confirm that library synthesis had been successful. Individu al compounds were also prepared to study the stability of compounds of this type.