SYNTHETIC METHODS FOR POLYAMINE LINKERS AND THEIR APPLICATION TO COMBINATORIAL CHEMISTRY

Polyamines and polyamine conjugates display a diverse range of importa nt biological functions, ranging from antibiotics to immunosuppressant s and glutamate receptor antagonists. For these reasons, polyamines pr ovide an excellent template/scaffold for combinatorial chemistry In th is paper we present methods for the solid-phase immobilisation of poly amines for use in synthetic and combinatorial chemistry and describe h ow they have been employed in the preparation of a number of important polyamine conjugates and polyamine libraries. Thus, we have designed, synthesised and utilised a number of polyamine linkers for both solut ion and resin screening combinatorial application.