XANTHINES AS A SCAFFOLD FOR MOLECULAR DIVERSITY

Authors
HEIZMANN G EBERLE AN
Citation
G. Heizmann et An. Eberle, XANTHINES AS A SCAFFOLD FOR MOLECULAR DIVERSITY, Molecular diversity, 2(3), 1997, pp. 171-174
Citations number
21
Categorie Soggetti
Chemistry Applied","Chemistry Medicinal
Journal title
Molecular diversity → ACNP
ISSN journal
13811991
Volume
2
Issue
3
Year of publication
1997
Pages
171 - 174
Database
ISI
SICI code
1381-1991(1997)2:3<171:XAASFM>2.0.ZU;2-H
Abstract
Xanthines represent a new, versatile scaffold for combinatorial chemis try. A five-step solid-phase synthesis of xanthine derivatives is desc ribed which includes alkylations, a nucleophilic displacement reaction at a heterocycle and a ring closure reaction by condensation of a nit roso function with an activated methylene group. The selected reaction sequence allows the production of a highly diverse small-molecule com binatorial compound library.