Sh. Mitchell et Wg. Teague, REDUCED GAS TRANSFER AT REST AND DURING EXERCISE IN SCHOOL-AGE SURVIVORS OF BRONCHOPULMONARY DYSPLASIA, American journal of respiratory and critical care medicine, 157(5), 1998, pp. 1406-1412
Citations number
36
Categorie Soggetti
Emergency Medicine & Critical Care","Respiratory System
School-age children who survive bronchopulmonary dysplasia (BPD) may h
ave a permanent reduction in alveolar surface area that could limit ga
s transfer both at rest and during exercise. To test this hypothesis,
10 survivors of BPD, 10 children born prematurely without BPD, and 10
healthy children born at term, 6 to 9 yr of age, underwent treadmill e
xercise studies. During a three-phase protocol we measured intrabreath
acetylene (C2H2) and carbon monoxide (CO) transfer, pulmonary functio
n, and Sa(O2). Both at rest and during exercise, C2H2 transfer correct
ed for body surface area was lower in survivors of BPD than it was in
children born prematurely without BPD or children born at term. With e
xercise the transfer of both gases increased sharply over resting valu
es in children born prematurely and at term. In survivors of BPD C2H2
transfer with exercise did increase, but not as much as it did in cont
rol subjects, and corrected CO transfer did not change at all. In surv
ivors of BPD and children born prematurely, FEV1 fell during recovery
from exercise, but this did not correlate with C2H2 transfer or DLCO/V
A. Thus, soluble gas transfer at rest and during acute exercise is red
uced in children who survive BPD. This is likely explained either by l
ong-term derangements in lung structure or residual right ventricular
dysfunction affecting cardiac output.