PULMONARY TOXICITY ASSOCIATED WITH NITRIC-OXIDE IN TERM INFANTS WITH SEVERE RESPIRATORY-FAILURE

Authors
HALLMAN M BRY K TURBOW R WAFFARN F LAPPALAINEN U
Citation
M. Hallman et al., PULMONARY TOXICITY ASSOCIATED WITH NITRIC-OXIDE IN TERM INFANTS WITH SEVERE RESPIRATORY-FAILURE, The Journal of pediatrics, 132(5), 1998, pp. 827-829
Citations number
14
Categorie Soggetti
Pediatrics
Journal title
The Journal of pediatrics → ACNP
ISSN journal
00223476
Volume
132
Issue
5
Year of publication
1998
Pages
827 - 829
Database
ISI
SICI code
0022-3476(1998)132:5<827:PTAWNI>2.0.ZU;2-9
Abstract
We prospectively analyzed airway specimens from 24 newborn infants. In haled nitric oxide (less than or equal to 20 ppm for 1 to 4 days to 12 infants) did not affect the concentrations of the lipid peroxidation product, the surface activity, or the cytokines (interleukin-l, granul ocyte-macrophage colony-stimulating factor, interleukin-l receptor ant agonist). Nitrotyrosine was detected after 10 days of life in the two infants requiring prolonged ventilation, suggesting toxicity of endoge nous nitric oxide.