Objective: The objective of this study was to determine the positive a
nd negative clinical predictors of intussusception and the correlation
of ultrasonography and air enema in establishing this diagnosis. Stud
y design: This was a prospective descriptive cohort study. Setting: Th
is study was performed in a tertiary care pediatric emergency departme
nt. Participants: Eighty-eight of 245 candidates were assessed for cli
nical predictors of intussusception. All 245 cases were examined for c
orrelation between ultrasonography and air enema. Interventions: A que
stionnaire, ultrasonography, and air enema were used. Results: Thirty-
five of the 88 patients assessed for clinical predictors were positive
for intussusception. Significant positive predictors were right upper
quadrant abdominal mass (positive predictive value [PPV] 94%), gross
blood in stool (PPV 80%), blood on rectal examination (PPV 78%), the t
riad of intermittent abdominal pain, vomiting, and right upper quadran
t abdominal mass (PPV 93%, p = 0.0001), and the triad with occult or g
ross blood per rectum (PPV 100%, p = not significant). Significant neg
ative predictors were a combination of greater than or equal to 3 of 1
0 clinically significant negative features (negative predictive value
77%, p = 0.035). Of the total 245 cases, intussusception (as confirmed
by doughnut, target, or pseudokidney sign) was ruled out by ultrasono
graphy in 97.4%. Alternate ultrasound findings comprised 27% of negati
ve cases. Conclusions: Excellent positive predictors of intussusceptio
n were identified prospectively. Although no reliable negative predict
ors were found, patients at low risk may be screened by ultrasonograph
y.