COINHERITANCE OF ALPHA-THALASSEMIA-1 AND HEMOGLOBIN E BETA(0)-THALASSEMIA - PRACTICAL IMPLICATIONS FOR NEONATAL SCREENING AND GENETIC-COUNSELING/

Hemoglobin E (HbE), alpha-thalassemia, and beta-thalassemia are common among Southeast Asians and often occur in compound heterozygous state s that complicate neonatal screening. We describe a kindred with alpha -thalassemia-1, HbE, and beta(0)-thalassemia. The proband had HbE/beta (0)-thalassemia, with severe anemia and failure to thrive. His father also had HbE/beta(0)-thalassemia but had coinherited a thalassemia-l a nd was free of symptoms.