H. Lenbartz et al., THE CLINICAL MANIFESTATION OF THE KWASHIORKOR SYNDROME IS RELATED TO INCREASED LIPID-PEROXIDATION, The Journal of pediatrics, 132(5), 1998, pp. 879-881
Along with the onset of severe kwashiorkor symptoms, a 20-month-old ch
ild showed biochemical signs of markedly increased lipid peroxidation,
with a decrease of plasma antioxidants and decreased proportions of p
olyunsaturated fatty acids in plasma and red cell phospholipids. Addit
ionally, plasma concentrations of the lipid peroxidation products malo
ndialdehyde and hexanal, as well as the urinary excretion of leukotrie
ne E-4, were found to be increased. AU biochemical alterations normali
zed along with subsequent clinical improvement. These findings suggest
that the extent of lipid peroxidation is strongly related to the seve
rity of the kwashiorkor syndrome.