Ph. Yu et Rf. Dyck, IMPAIRMENT OF METHYLAMINE CLEARANCE IN UREMIC PATIENTS AND ITS NEPHROPATHOLOGICAL IMPLICATIONS, Clinical nephrology, 49(5), 1998, pp. 299-302
The urinary levels of methylamine were analyzed by an HPLC/fluorometri
c method following derivatization of the amine with O-phthaldialdehyde
(OPA). The excretion of methylamine in the uremic patients was found
to be dramatically reduced. The impairment of clearance of methylamine
explains why this amine was substantially increased in the serum of u
remic patients. Increased deamination of methylamine would enhance for
maldehyde and oxidative stresses, i.e. in the blood vessels, and cause
vascular damage. This may be related to the increased risk of angiopa
thy associated with renal failure, and accelerate the progression of r
enal failure.