RELATIONSHIP BETWEEN SERUM PARATHYROID-HORMONE LEVELS AND LIPID PROFILE IN HEMODIALYSIS-PATIENTS - EVOLUTION OF LIPID PARAMETERS AFTER PARATHYROIDECTOMY

To determine the influence of parathyroid hormone (PTH) on lipid distu rbances of uremia, the lipid profile was determined in 34 hemodialysis (HD) patients, comparing lipid parameters among subjects classified a ccording to their intact PTH level. Furthermore, the effect of correct ion of severe secondary hyperparathyroidism on serum lipids was evalua ted in 7 patients after parathyroidectomy. Total cholesterol, high-den sity lipoproteins (HDL), triglycerides, apolipoproteins A-I and B-100 (Apo B and Apo B), lipoprotein(a) and the ratios of cholesterol/HDL an d Apo A/Apo B were analyzed. There was no correlation between serum li pids and PTH levels in the total group. Lipid profile was similar amon g patients classified according to their PTH level. No correlations we re observed in either group between Lipids and PTH. Lipid profile did not change in the seven patients with severe secondary hyperparathyroi dism after parathyroidectomy. In conclusion, there was no relationship between PTH and lipids and risk ratios in HD patients. Lipid profile did not change in patients with severe secondary hyperparathyroidism a fter parathyroidectomy. These findings suggest that PTH does not play a significant role in the dyslipidemia of renal failure.