SYNTHESIS OF SOME NOVEL 2-OXO-PYRANO(2,3-B)-QUINOLINE AND 2-OXO-PYRIDO(2,3-B)QUINOLINE DERIVATIVES AS POTENTIAL ANTIMALARIAL, DIURETIC, CLASTOGENIC AND ANTIMICROBIAL AGENTS

The 2-chloro-3-formyl quinoline derivatives (1a-e) on treatment with a cetic anhydride and sodium acetate, afforded the corresponding novel 2 -oxo-pyrano(2,3-b) quinoline derivatives (2a-e), and these were subjec ted to ammonia treatment to yield the corresponding naphthyridine deri vatives (3a-e). The prepared compounds (2a-e) were tested for their an timalarial, diuretic, clastogenic and antimicrobial properties. Not al l the compounds showed a diuretic effect and the significant increase in the frequency of micronuclei shows that they are non-clastogens, wh ereas the 7-chloro derivative (2e) was a very effective antimalarial a gent against the mosquito species. All the compounds were found to hav e optimum antimicrobial activity against Staphylococcus aureus, Escher ichia coli and Salmonella typhi. Compounds 2d and 2e were found to be most active against the bacteria tested. (C) 1998 SCI.