PAPILLOMAVIRUS-INDUCED GENITAL WARTS IN A GIRL - MANAGEMENT BY SURGERY AND IMMUNOMODULATING THERAPY

A 4-year-old girl with condylomata acuminata of the vulva and papular warts of the surrounding skin is presented. The lesions were removed b y surgery. Histologic investigation showed koilocytosis of the squamou s epithelium and in-situ hybridization revealed human papilloma virus type 6 infection. There were no signs of sexual abuse or sexual transm ission of the virus. After ablation, an interferon-containing ointment was applied. In order to prevent recurrence, a low-molecular-weight i mmunomodulating leucocyte fraction was given for more than 1 year, dur ing which time no relapse was observed.