DETECTION AND ISOLATION OF A NOVEL HUMAN GENE LOCATED ON XP11.2-P11.4THAT ESCAPES X-INACTIVATION USING A 2-DIMENSIONAL DNA MAPPING METHOD

Using a two-dimensional DNA mapping method, we detected four NotI rest riction sites that escape chromosome X-specific methylation in humans. Two genes corresponding to two of these sites that lie in the region of Xp11.2-p11.4 were cloned and their properties studied. One of the g enes matched a known gene, but the other, termed EXLM1, is novel and i s predominantly expressed in cultured lymphocytes and skeletal muscle. (C) 1998 Academic Press.