PREDICTIVE DOCKING OF PROTEIN-PROTEIN AND PROTEIN-DNA COMPLEXES

Authors
STERNBERG MJE GABB HA JACKSON RM
Citation
Mje. Sternberg et al., PREDICTIVE DOCKING OF PROTEIN-PROTEIN AND PROTEIN-DNA COMPLEXES, Current opinion in structural biology, 8(2), 1998, pp. 250-256
Citations number
45
Categorie Soggetti
Cell Biology",Biology
Journal title
Current opinion in structural biology → ACNP
ISSN journal
0959440X
Volume
8
Issue
2
Year of publication
1998
Pages
250 - 256
Database
ISI
SICI code
0959-440X(1998)8:2<250:PDOPAP>2.0.ZU;2-4
Abstract
Recent developments in algorithms to predict the docking of two protei ns have considered both the initial rigid-body global search and subse quent screening and refinement. The results of two blind trials of pro tein docking are encouraging - for complexes that are not too large an d do not undergo sizeable conformational change upon association, the algorithms are now able to suggest reasonably accurate models.