Any operation for lung cancer that is planned as curative includes dis
section of the lymph nodes in the mediastinum in order to allow correc
t staging of the disease. It is well known that ipsilateral lymph node
metastases (N2) mean a poor prognosis. Since most patients with this
finding die from metastatic tumor progression within 3 years after the
operation, it can be assumed that positive findings in the mediastina
l lymph nodes represent generalization of the cancer. Therefore, the p
robability of a therapeutic effect from more radical removal of lymph
nodes in the mediastinum is rather low. On the other hand, it is justi
fied to apply and evaluate additional systemic treatment in these tumo
r stages.