UVEITIS, ARTHRALGIA AND PSEUDO-JAUNDICE I N A HIV SERONEGATIVE PATIENT GIVEN RIFABUTIN

Rifabutin is an effective drug ii? the treatment of Mycobacterium aviu m complex (MAC). Rare adverse effects have been described in non immun ocompromised patients. We report the case of a 35 year-old woman, nega tive for the human immunodeficiency virus (HN), who had nit isolated p ulmonary infection caused by MAC. Under Rifabutin (600 mg/day), Clarit hromycin and Ethambutol, an uveitis, associated with a pseudojaundice and polyarthralgia, appealed while pulmonary infection improved. Impro vement of adverse effects tvas obtained with non-steroid anti-inflamma tory drugs, local steroid treatment for uveitis and lower closes of Ri fabutin (300 mg/day). Those adverse effects have not been previously d escribed with this dose of Rifabutin in a non HN patient. The mechanis m remained unknown. The decrease of Rifabutin doses associated with sy mptomatic treatments allow the preservation of an effective treatment for MAC infection.