Objective: To test the hypothesis that standardizing the process of we
aning from mechanical ventilation would decrease ventilation times and
length of stay in a surgical intensive care unit. Design: Comparison
of historic ventilation times with physician-directed weaning with tho
se obtained with protocol-guided weaning by respiratory therapists.Set
ting: Urban, teaching surgical intensive care unit with open admission
policy and no dominant diagnosis related group. Results: From January
1, 1995, through December 31, 1995, 378 patients who underwent physic
ian-directed weaning from a ventilator had 64 488 hours of ventilation
, compared with 57 796 ventilation hours in 515 patients with protocol
-guided weaning (April 1, 1996, through May 31, 1997). The mean hours
of ventilation decreased by 58 hours, a 46% decrease (P<.001). The len
gth of hospital stay decreased by 1.77 days (29% change), while the Ac
ute Physiology and Chronic Health Evaluation III score remained at 50
to 51. The number of reintubations did not change. The marginal cost s
avings was $603 580. Conclusion: Protocol-guided weaning from mechanic
al ventilation leads to more rapid extubation than physician-directed
weaning and has great potential for cost savings.