ROOM-TEMPERATURE PHOSPHORIMETRIC METHOD FOR THE DETERMINATION OF THE DRUG NAPHAZOLINE IN PHARMACEUTICAL PREPARATIONS

Authors
CARRETERO AS BLANCO CC DIAZ BC GUTIERREZ AF
Citation
As. Carretero et al., ROOM-TEMPERATURE PHOSPHORIMETRIC METHOD FOR THE DETERMINATION OF THE DRUG NAPHAZOLINE IN PHARMACEUTICAL PREPARATIONS, Analyst, 123(5), 1998, pp. 1069-1071
Citations number
11
Categorie Soggetti
Chemistry Analytical
Journal title
Analyst → ACNP
ISSN journal
00032654
Volume
123
Issue
5
Year of publication
1998
Pages
1069 - 1071
Database
ISI
SICI code
0003-2654(1998)123:5<1069:RPMFTD>2.0.ZU;2-Y
Abstract
A selective and sensitive micelle-stabilized room-temperature phosphor imetric (MS-RTP) method for the determination of naphazoline in pharma ceutical preparations is described. The method is based on obtaining a phosphorescence signal from naphazoline using a micellar agent (sodiu m dodecyl sulfate), a heavy atom salt (TlNO3) and a deoxygenation agen t (Na2SO3). Optimization of the various conditions permitted the estab lishment of an MS-RTP method for naphazoline determination with a dete ction limit of 64.2 ng ml(-1) and a relative standard deviation of 3.7 4% at the 500 ng ml(-1) level. The method was applied to the analysis of pharmaceutical preparations.