A simple and relatively rapid enzyme-linked immunosorbant assay method
for the anti-emetic drug ondansetron has been developed for its quant
itation in solution. This has been optimised for use with samples that
have been obtained following extraction of filters after the drug's c
apture from air samples in the workplace. The assay has the sample thr
oughput (40 duplicate samples in 3 h), specificity, sensitivity (LOD o
f 10.5 ng drug ml(-1)) and precision (RSD < 11%) necessary for its use
in determining airborne concentrations of ondansetron in such samples
as part of an occupational health and hygiene monitoring programme.