W. Cronin et al., PSEUDO-OUTBREAK OF TUBERCULOSIS IN AN ACUTE-CARE GENERAL-HOSPITAL - EPIDEMIOLOGY AND CLINICAL IMPLICATIONS, Infection control and hospital epidemiology, 19(5), 1998, pp. 345-347
A 10-fold increase in patients with Mycobacterium tuberculosis-positiv
e specimens in one hospital laboratory prompted an investigation. Clin
ical and epidemiological data, along with M tuberculosis DNA fingerpri
nting results, indicated that laboratory contamination led to nine fal
se-positive M tuberculosis cultures. Pseudo-infection should be consid
ered in patients with unusual tuberculosis presentations, negative aci
d-fast bacilli smears, and only one positive culture with a low colony
count (Infect Control Hosp Epidemiol 1998;19:345-347).