A. Anvari et al., EFFECTS OF LIDOCAINE, AJMALINE, AND DILTIAZEM ON VENTRICULAR DEFIBRILLATION ENERGY-REQUIREMENTS IN ISOLATED RABBIT HEART, Journal of cardiovascular pharmacology, 29(4), 1997, pp. 429-435
The majority of patients with implanted cardioverter defibrillators (I
CD) require antiarrhythmic (AR) drugs. ARs may increase defibrillation
energy requirements. This study investigated the effects of lidocaine
, ajmaline, and diltiazem on ventricular defibrillation energy needs.
In 24 isolated rabbit hearts, the 50 and 80% successful defibrillation
en energy (ED50, ED80) was calculated in four phases: predrug baselin
e condition (phase 1), and phases 2, 3, and 4 with increasing concentr
ations of lidocaine, ajmaline, diltiazem (n = 18). Control experiments
(n = 6) with only Tyrode's solution infusion indicated that the prepa
ration was stable over time. Defibrillation energy requirements signif
icantly (p < 0.05) increased with all ARs. Low, medium, and high lidoc
aine concentrations increased ED50 and ED80 to 146, 223, and 312% and
139, 207, and 285%, respectively. Ajmaline increased ED50 and ED80 to
133, 175, and 251% and 135, 208, and 285%, respectively. Diltiazem inc
reased ED50 and ED80 by 175, 236, and 334% and 158, 212, and 286%, res
pectively. The results of this study demonstrate a dose-dependent incr
ease in defibrillation energy requirements by using lidocaine, diltiaz
em, and ajmaline. In patients with ICDs, administration of these drugs
might cause a critical increase in defibrillation energy requirements
, resulting in device failure.