INVESTIGATION OF THE METABOLISM OF 7-(4-CHLORBENZYL)7,8,13,13A-TETRAHYDROBERBERINE CHLORIDE IN THE RAT

Authors
FENG N ZHANG Z AN D HUANG W WANG G HAN X BAO X
Citation
N. Feng et al., INVESTIGATION OF THE METABOLISM OF 7-(4-CHLORBENZYL)7,8,13,13A-TETRAHYDROBERBERINE CHLORIDE IN THE RAT, European journal of drug metabolism and pharmacokinetics, 23(1), 1998, pp. 41-44
Citations number
1
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of drug metabolism and pharmacokinetics → ACNP
ISSN journal
03787966
Volume
23
Issue
1
Year of publication
1998
Pages
41 - 44
Database
ISI
SICI code
0378-7966(1998)23:1<41:IOTMO7>2.0.ZU;2-2
Abstract
The metabolism of 7-(4-chlorbenzyl)-7,8,13,13a-tetrahydroberberine chl oride (CTHB), a compound with promising pharmacological effects agains t arrhythmia, was investigated in rat bile. A metabolite and unchanged CTHB were found in the bile. Characterization and structural elucidat ion of the metabolite was achieved by LC/MS and LC/NMR. The following metabolic pathway is proposed: CTHB is metabolized by demethylation at position 10 to produce a new entity.